Does Comfortis have side effects?
Matthew Shields
Updated on March 15, 2026
Does Comfortis have side effects?
Comfortis side effects The initial studies and post-approval data for Comfortis list the side effects for a small number of dogs (in decreasing order of frequency) as: vomiting, depression and lethargy, anorexia, ataxia, diarrhea, pruritus (itching), trembling, hypersalivation and seizures.
Is Comfortis killing dogs?
A family says the drug, Comfortis, killed their dog. A Clearwater man says the same thing happened to his 12-year-old dog after he gave him a dose of a similar drug, Trifexis, used for heartworm prevention. Both drugs are made by the company Elanco and have the same active ingredient, Spinosad.
Has Comfortis been discontinued?
We’re discontinuing to sell Comfortis, a monthly flea control for dogs and cats, to make room for newer products. We marked down the last few boxes and singles to get them out of our way.
Can my dog be allergic to Comfortis?
Allergic reactions and sensitivity Most dogs tolerate Comfortis well, and adverse reactions are uncommon. The most common side effect of a spinosad sensitivity is vomiting.
Is Comfortis toxic to humans?
Warnings: Not for human use. Keep this and all drugs out of the reach of children. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with Comfortis (see POST APPROVAL EXPERIENCE).
How long does it take Comfortis to digest?
It’s quite a common side effect, usually 2 hours is enough for the tablet to be absorbed, under two hours it’s usually recommend to treat again.
Which is safer Comfortis or NexGard?
Winner: NexGard Though NexGard is a bit more expensive than Comfortis, it works against more parasites than Comfortis. Additionally, it is safe for younger puppies and has fewer side effects.
Is spinosad poisonous to dogs?
The most common clinical sign of spinosad toxicity in the dog is vomiting. Other clinical signs are inappetence, lethargy, diarrhea, coughing, and polydipsia. Rare clinical signs include erythema, salivation, pruritis, and trembling. Spinosad may lower the seizure threshold in epileptic dogs.
How long does Comfortis stay in system?
KILL FLEAS ON YOUR DOG OR CAT. Comfortis® (spinosad) starts killing fleas in 30 minutes, before they can lay eggs. Plus, Comfortis lasts a whole month—it can’t be washed, rubbed or shaken off.
Can I split Comfortis in half?
So if you’re using tablets, such as Comfortis, Sentinel, or Program Tablets, to prevent and kill fleas, don’t split them unless your veterinarian specifically instructs you to do so.
Is Capstar the same as Comfortis?
They both come in the form of a convenient, chewable tablet. Each of these medications work rapidly (Comfortis starts killing fleas within 30 minutes, and Capstar kills 90% of fleas within 4 hours). Capstar is available without a prescription, while Comfortis is available only with a prescription from a veterinarian.
Is Comfortis safe for older dogs?
Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Use only for cats and kittens 14 weeks of age or older and 4.1 pounds of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5.0 pounds of body weight or greater.
Are Comfortis flea tablets for dogs safe?
However, when compared with products currently on the market, Comfortis Flea Tablets for Dogs have a good safety profile with few side effects. Comfortis has a high degree of safety, and compares favourably with other brand name flea control products.
What are the side effects of Comfortis?
Comfortis has a high degree of safety, and compares favourably with other brand name flea control products. Side effects are rare and usually minor in severity if they occur i.e. intestinal upset (see side effects information below).
How long does it take for Comfortis to kill fleas?
In a well-controlled laboratory study, Comfortis began to kill fleas 30 minutes after administration and demonstrated 98% effectiveness within 4 hours. Comfortis kills fleas before they can lay eggs.
Does Comfortis make dogs throw up?
What may be surprising to some is that Comfortis dogs were only 0.5% (half a percent) more likely to vomit than dogs receiving a non-oral (spot-on) brand-name flea treatment. Lose stools were also slightly more likely in dogs treated with Comfortis. To avoid this reaction, always make sure that the dose of Comfortis is given with a full meal.