Is the RhoGAM shot given in the arm?
William Burgess
Updated on March 17, 2026
Is the RhoGAM shot given in the arm?
If there are no antibodies, you can take a medicine (RhoGAM®) to prevent your blood from reacting against your baby’s blood. RhoGAM is given as an injection (shot) in your arm at 28 to 32 weeks of pregnancy, within 72 hours of giving birth to an Rh positive baby, or both.
How do you administer anti RhoGAM?
RhoGAM is injected into a muscle or a vein. You will receive this injection in a clinic or hospital setting. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely after you receive immune globulin. Your urine may also need to be tested every 2 to 4 hours for at least 8 hours.
In what cases should the administration of RhoGAM be considered?
Pregnancy and Other Obstetrical Conditions in Rh-Negative Women, Unless the Father or Baby are Conclusively Rh Negative
- Pregnancy/delivery of an Rh-positive baby irrespective of the ABO groups of the mother and baby.
- Abortion/threatened abortion at any stage of gestation.
- Ectopic pregnancy.
When do you administer RhoGAM?
Your doctor will administer at least one dose of RhoGAM Ultra-Filtered PLUS between 26 and 28 weeks of pregnancy. If your baby is found to be Rh-positive at birth, you will receive an additional dose within 72 hours after delivery. Your doctor will determine the appropriate dose of RhoGAM after delivery.
Where do you give a RhoGAM shot?
RhoGAM is a prescription drug typically given by injection into a muscle — often in the backside, so just another indignity you’ll deal with while pregnant. It can also be given intravenously. Your doctor will decide what’s the appropriate dose for you. RhoGAM is effective for about 13 weeks.
Does Rh shot hurt?
RhoGAM is a sterilized solution made from human blood that contains a very small amount of Rh-positive proteins. These proteins keep your immune system from making permanent antibodies to Rh-positive blood. They do not hurt your baby. RhoGAM is given as an injection (shot).
Why is RhoGAM administered?
The purpose of the RhoGAM shot is to prevent problems that occur due to the baby’s positive blood type. It helps prevent the body from developing Rh antibodies. Antibodies are proteins that our immune system makes to fight against foreign substances.
What happens if you give RhoGAM to a Rh positive person?
RhoGAM stops your blood from making antibodies that kill Rh‐positive blood cells. The drug is derived from donated human plasma (a blood product) and has a very small amount of Rh‐positive protein that stops your body from making permanent antibodies against Rh‐positive blood.
What are the indications for RhIG?
An FDA-approved RhIG product exists for each of the following indications:
- Immune thrombocytopenic purpura (ITP) Rh(D)-positive, non-splenectomized. Chronic ITP in children and adults.
- Rh isoimmunization suppression. Rh(D)-negative, non-sensitized patient with Rh-incompatible fetus.
What route is RhoGAM?
RhoGAM(R): Rhophylac(R): 100 international units (20 mcg) per 2 mL transfused blood (or per 1 mL erythrocyte concentrate), IM or IV, within 72 hours of exposure. -Administer 3,000 international units (600 mcg) IV every 8 hours until the total dose (calculated from the above doses) is administered.
Why are RhoGAM injections given?
RhoGAM is an immunity support injection administered during pregnancy for people with a negative blood type. The purpose of the RhoGAM shot is to prevent problems that occur due to the baby’s positive blood type. It helps prevent the body from developing Rh antibodies.
What should you assess before giving RhoGAM?
Blood and urine tests may be needed to check for unwanted effects. Check with your doctor right away if you or your child have back pain; shaking chills; a fever; dark urine; a decreased amount of urine; a sudden weight gain; swelling of the hands or feet; or shortness of breath after receiving this medicine.