What is evicel used for?
Andrew Henderson
Updated on March 07, 2026
What is evicel used for?
What is Evicel used for? Evicel is a medicine that is used as a sealant (glue). It is available as two solutions, one containing the active substance human clottable protein (50 to 90 mg/ml), and the other containing the active substance human thrombin (800 to 1200 international units per millilitre).
What is Evicel fibrin sealant?
Evicel (fibrin sealant, human) is a fibrin sealant indicated as an adjunct to hemostasis for use in patients undergoing surgery, when control of bleeding by standard surgical techniques (such as suture, ligature or cautery) is ineffective or impractical.
How long does it take evicel to thaw?
The vials should be thawed in one of the following ways: 2°C-8°C (refrigerator): vials thaw within 1 day, or 20°C-25°C (room temperature): vials thaw within 1 hour, or 37°C (e.g., water bath, using aseptic technique, or by warming vials in the hand): vials should be thawed within 10 minutes and must not be left at this …
What is the minimum distance from tissue to obtain an optimal spray pattern when spraying EVICEL solutions for sealant using the airless spray accessory tip?
Position the tip at least 2 cm away from the target tissue. Apply firm even pressure to the plunger to spray the fibrin sealant.
How long does evicel last?
Deep frozen EVICEL® has a shelf life of 2 years. The vials must be stored in an upright position The expiry date is stated on the package….
| Study # | 2 |
|---|---|
| No. of Patients (EVICEL®/Control) | 147 (75/72) |
| Surgical Procedure | Vascular |
| Primary Efficacy Results (EVICEL® vs. Control) | 85.3% vs. 38.9% |
| P-Values | p<0.001 |
How long does fibrin glue take to work?
The more concentrated thrombin solution, thrombin 500, produces a fibrin clot in about 10 seconds and the more dilute thrombin solution, thrombin 4, results in a clot in about 60 seconds after glue application to the surgical field.
What do fibrin sealants do?
Fibrin glue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis or wound healing. It contains separately packaged human fibrinogen and human thrombin.
Is evicel human tissue?
EVICEL® is a human plasma-derived fibrin sealant. EVICEL® is supplied as a package containing two separate vials (glass type I) with rubber stoppers (type I), each containing 2 ml or 5 ml clear or slightly opalescent solution of Fibrinogen and Thrombin (Human), respectively.
What is Vistaseal made of?
VISTASEAL Fibrin Sealant (Human) contains a combination of fibrinogen and thrombin, clotting proteins found in human plasma. When applied to the bleeding site, it forms a rapid, adherent, and durable cloti and has been demonstrated to sustain hemostasis (stoppage of bleeding), even in high-risk patients.
What is the side effects of fibrin?
Fibrin sealant topical side effects
- chest pain, cough, trouble breathing, gasping for breath;
- confusion, agitation, panic, extreme fear;
- sudden numbness or weakness (especially on one side of the body);
- sudden severe headache, slurred speech, problems with vision or balance;
- blue-colored appearance of your skin or lips;
Is fibrin glue a blood product?
PG and platelet fibrin glue are made from single blood donations (platelet concentrates combined or not with cryoprecipitate).
Is fibrin FDA approved?
Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA).
Can the Evicel™ laparoscopic airless spray accessory be used for spraying?
EVICEL™ Laparoscopic Airless Spray Accessory (35 cm Rigid) can be used for spraying as assembled. EVICEL™ Laparoscopic Airless Spray Accessory (35 cm Rigid) can be used for dripping.
How do I use the airless spray accessory (35 cm rigid)?
Once the Airless Spray Accessory and Laparoscopic Airless Spray Accessory (35 cm Rigid) is firmly attached, do not depress plungers to prime device until intended use because the two biologic components will pre-mix in the spray tip, forming a fibrin clot that prevents dispensing. Position the tip at least 2 cm away from the target tissue.
How thick can you Spray Evicel?
As an approximate guide, if a layer of 1 mm thickness is produced by spraying EVICEL®, the surface areas that can be covered by each of the kit sizes are given in Table 1. Use standard surgical techniques for hemorrhagic control, including suture, ligature and cautery prior to the application of EVICEL®.
Who should use Evicel®?
EVICEL®, the application device and accessory tips should only be used by persons trained in laparoscopic, laparoscopic-assisted, endoscopic or open surgical procedures. Prepare and administer EVICEL ® according to the instructions and with only devices recommended for this product.
